By The Night Shift Co.
We're not going to hide behind a proprietary blend. Every ingredient in NOC is listed at its full dose on the label, and every one was selected for a specific reason tied to published research on shift work, circadian disruption, and the cellular damage that comes from working against your biology.
Here's exactly what's in each sachet, what it does, and why it matters for night shift workers specifically.
PQQ (BioPQQ®) — 20mg
What it does: PQQ — pyrroloquinoline quinone — is one of the few compounds shown to stimulate mitochondrial biogenesis, meaning it helps your body create entirely new mitochondria. It also acts as a potent antioxidant and supports sleep quality.
Why it matters for night shift: Chronic circadian disruption impairs mitochondrial function. Your cells' energy factories stop working efficiently, which is a major driver of the deep fatigue that sleep alone doesn't fix. PQQ doesn't just support your existing mitochondria — it helps your body build new ones to replace the damaged ones. It also has neuroprotective properties relevant to the cognitive decline associated with long-term shift work.
Why BioPQQ®: BioPQQ is the most clinically studied form of PQQ, produced through a natural fermentation process. It's the form used in the research we're referencing.
CoQ10 (Ubiquinol) — 100mg
What it does: CoQ10 is essential for mitochondrial electron transport — it's literally part of the chain reaction that produces cellular energy (ATP). Ubiquinol is the active, reduced form that your body can use immediately.
Why it matters for night shift: If PQQ builds new mitochondria, CoQ10 makes sure they run efficiently. The two are synergistic — research shows they work significantly better together than either alone. CoQ10 also acts as a fat-soluble antioxidant, protecting cell membranes from oxidative damage.
Why Ubiquinol, not Ubiquinone: Most cheap CoQ10 supplements use ubiquinone, which your body has to convert to ubiquinol before it can use it. That conversion becomes less efficient with age and under stress. We use the active form so it works immediately.
Rhodiola Rosea — 300mg
What it does: Rhodiola is an adaptogen — a class of compounds that help your body maintain balance under chronic stress. It has strong clinical evidence for supporting mood, reducing fatigue, and regulating cortisol.
Why it matters for night shift: Night shift is chronic stress, full stop. Your cortisol rhythm gets scrambled — instead of a clean peak in the morning and decline at night, shift workers often have flattened, dysregulated cortisol patterns. This manifests as that "wired but tired" feeling, mood instability, and difficulty recovering. Rhodiola helps your stress response system function more normally under abnormal conditions.
L-Theanine (Suntheanine®) — 200mg
What it does: L-theanine is an amino acid found naturally in green tea. It promotes calm focus by increasing GABA, serotonin, and dopamine activity in the brain. It also produces alpha brain waves — the same pattern associated with relaxed alertness and meditation.
Why it matters for night shift: Combined with caffeine at roughly a 2:1 ratio (which is how it's dosed in NOC), L-theanine has been shown in multiple randomized controlled trials to improve alertness, attention, and task-switching accuracy while eliminating the jitters and crash that caffeine alone causes. You get focused without feeling wired.
Why Suntheanine®: Suntheanine is the patented, pure L-isomer form produced via enzymatic fermentation — not extracted from tea leaves, which can contain a mix of isomers. It's the form used in the clinical research.
Green Tea Caffeine — 50mg
What it does: Provides clean, natural-source caffeine for alertness.
Why 50mg: This is intentionally low — roughly equivalent to half a cup of green tea, or about a quarter of a standard coffee. NOC is not an energy product. We included just enough caffeine to synergize with the L-theanine for cognitive performance, without enough to cause jitters, anxiety, or sleep disruption after your shift. The L-theanine buffers it completely.
Why this matters: Most night shift workers already drink coffee on shift. NOC is designed to work alongside your existing caffeine intake early in the shift, not replace it or add a stimulant spike that wrecks your morning sleep.
Vitamin D3 — 2,500 IU
What it does: Supports bone health, immune function, mood regulation, and energy metabolism. Vitamin D receptors exist in nearly every tissue in your body.
Why it matters for night shift: Approximately 80% of shift workers show Vitamin D deficiency or insufficiency because you're sleeping through peak sun hours. Deficiency is linked to increased depression risk, impaired immunity, chronic fatigue, and metabolic dysfunction — all things night shift workers already struggle with. This is arguably the single most impactful deficiency to correct.
Magnesium L-Threonate (Magtein®) — 150mg
What it does: Magnesium is involved in over 300 enzymatic reactions in the body, including energy production, muscle function, and nervous system regulation. Magnesium L-Threonate is unique because it's the only form clinically demonstrated to cross the blood-brain barrier and increase brain magnesium levels.
Why it matters for night shift: Most people are already magnesium deficient. Night shift workers are doubly at risk due to stress, poor dietary patterns, and disrupted absorption. The brain-specific delivery of Magtein is particularly relevant because it supports cognitive function, sleep quality, and stress resilience — three things that are directly compromised by shift work.
B-Complex (Full Spectrum, Methylated)
What it does: B1, B5, B6 (as P-5-P), and B12 (as methylcobalamin) support energy metabolism at the cellular level, nervous system function, and — critically — melatonin synthesis.
Why it matters for night shift: Your body needs B-vitamins to produce melatonin, the hormone that initiates sleep. When your B-vitamin status is low (common in night shift workers due to stress, poor nutrition, and irregular eating patterns), your body's ability to produce melatonin is compromised — making it even harder to fall asleep during the day.
Why methylated forms: Standard B-vitamins (cyanocobalamin, pyridoxine) require your body to convert them into active forms. Methylated forms — P-5-P and methylcobalamin — are already active and ready to use. This matters more for people with MTHFR gene variations (roughly 40% of the population), but it's better absorption for everyone.
DHA (Algal Source) — 200mg
What it does: DHA is an omega-3 fatty acid that makes up a significant portion of your brain's structural fat. It supports neuronal communication, reduces neuroinflammation, and protects brain structure over time.
Why it matters for night shift: Chronic shift work is associated with increased markers of neuroinflammation and accelerated cognitive decline. DHA provides direct structural and anti-inflammatory support for the brain under these conditions. It's not something you feel acutely — it's long-term brain protection.
Why algal source: Vegan-friendly, sustainably sourced, and avoids the heavy metal concerns that can come with fish-derived omega-3s. Same DHA, cleaner source.
Glutathione (Setria®) — 100mg
What it does: Glutathione is your body's master antioxidant — the primary defense system against oxidative stress and DNA damage at the cellular level.
Why it matters for night shift: Glutathione production follows a circadian rhythm, and night shift disrupts it. This means your body's antioxidant defenses are compromised at exactly the time they're under the most stress. Replenishing glutathione directly addresses the oxidative damage that accumulates from chronic circadian disruption.
Why liposomal delivery is critical for glutathione: Standard oral glutathione supplements have notoriously poor bioavailability — your stomach acid breaks down the molecule before it can be absorbed. Most of what you're paying for in a glutathione capsule never reaches your bloodstream. Liposomal encapsulation protects the glutathione through digestion and delivers it intact. This is one of the primary reasons NOC uses liposomal delivery for the entire formula.
Quercetin — 100mg
What it does: A flavonoid with potent anti-inflammatory and antioxidant properties. Also supports immune function and has been studied for its role in reducing inflammatory markers.
Why it matters for night shift: Circadian disruption drives chronic low-grade inflammation throughout the body. This contributes to joint pain, fatigue, brain fog, and increased disease risk over time. Quercetin helps manage this inflammatory burden alongside the glutathione and Vitamin C.
Vitamin C — 100mg
What it does: Supports immune defense, acts as an antioxidant, and — less commonly known — serves as a cofactor in melatonin synthesis.
Why it matters for night shift: Double duty. It supports the immune system that circadian disruption weakens, and it helps your body produce the melatonin it needs for daytime sleep. Most people think of Vitamin C as just an immune supplement, but its role in melatonin production makes it particularly relevant for shift workers.
Why Liposomal Delivery
Standard pills and capsules have to survive your stomach acid and pass through your intestinal lining to reach your bloodstream. For many compounds — especially glutathione, CoQ10, and PQQ — typical oral absorption rates are 10-20%. You're paying for a label dose that your body barely receives.
Liposomal delivery wraps the active ingredients in phospholipid bubbles (the same material your cell membranes are made of). These liposomes protect the compounds through digestion and fuse directly with your cells, delivering the ingredients at absorption rates of 50-90%.
It's the same technology used in pharmaceutical drug delivery systems and some mRNA vaccines. It's why you feel NOC working within 20-30 minutes — because the compounds are actually reaching your bloodstream at levels that make a difference.
The Bottom Line
Every ingredient in NOC is there for a documented reason tied to the specific biology of night shift work. Nothing is included for label decoration. Nothing is underdosed. Nothing is hidden behind a proprietary blend.
Twelve ingredients. Clinical doses. Liposomal delivery. Built by night shift nurses for the 15 million Americans working against their circadian clock.
Or grab our free Night Shift Survival Protocol — a 25-page guide covering sleep, nutrition, training, energy management, and supplementation for night shift workers.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.